Brennan and Booth travel to Mexico to investigate human remains with extraterrestrial attributes; Angela and intern Wendell come clean about their relationship.
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Christian refuses to operate on a model who wants to drastically alter her appearance, and a man who was in a coma for decades wants Sean to make him look younger. Meanwhile, Kimber redecorates Sean’s new apartment.
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Things begin to heat up for Jules and Scott, and she freaks out about it. While Laurie tries to have sex with a friend and Andy reveals his big secret.
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Tom begins mixing with people Gary and Allison don’t approve of, so naturally they have to pry into his life. Sasha becomes fond of pro surfer Laird Hamilton.
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A drug dealer collapses during a sale, but refuses to reveal personal information to the team because it might incriminate him. Meanwhile, Foreman’s teammates conspire to play a practical joke on him, while House and Wilson both aim their sights on an attractive new neighbor, Nora.
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Barney chooses between wearing suits and sleeping with a sexy bartender. Meanwhile, Ted gets ever closer to meeting “the mother”.
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Chuck must protect a visiting dictator from an assassination threat; Awesome is excited about the idea of being a spy.
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When Season and Christian win a prestigious award from their alma mater, Sean recalls their college years and endures past pains. A new patient who self-mutilates due to a genetic disorder comes to McNamara/Troy for reconstructive surgery.
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Betty wants to spend some time apart from Matt, so finds him something else to keep him occupied. Meanwhile, Hilda has a tough decision to make regarding her baby, and Mark’s fling looks to be heading towards something more serious.
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As Claire becomes immersed into the world of the Carnival, she becomes increasingly suspicious of Samuel’s motives. Hiro is on a mission to rescue one of his own, but has difficulty communicating his intentions to Ando. Samuel has his sight set on Emma and her ability to complete his master plan. Meanwhile, Sylar returns to the Carnival in search of answers and Peter continues to struggle with the loss of his brother.
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