While Cuddy deals with her personal relationships, House is finally reinstated and takes on the case of a porn star with eye pain.
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House, Cuddy, and Wilson go to a medical conference and meet an old friend, while the team deal with a girl whose appendages have swollen but she refuses to tell them the truth about the events leading up to her illness.
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A dying patient insists that he has the same disease affecting his heart that killed his father and grandfather at the age of 40. Meanwhile, House discovers that he has a hearing problem while trying to duck student rounds.

A wealthy businessman brings his teenage son to the hospital and insists on having House handle the case; Foreman and Chase prepare to present information on the Dibala case.
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House’s team struggles with an African politician who falls ill and decide if they want to help him after he’s charged for crimes against humanity in his country.

House returns home to Princeton where he continues to focus on his recovery, but surprises Cuddy with the news that he’s making a big change in his life. Meanwhile, the team is unable to diagnose a loud-mouthed video game creator who posts each new symptom on the internet and opts for treatments suggested by the online community rather than by the doctors, and Foreman angles for House’s job, but the pressure to solve the case creates tension in his relationship with Thirteen.

House checks in the psychiatric hospital and meets a few new characters including his roommate Alvie (guest star Lin-Manuel Miranda) and Dr. Nolan (guest star Andre Braugher).