Everyone is packing their bags and heading home for Thanksgiving, but Casey and Rusty find themselves stranded at CRU when their parents leave them behind for Maui. Will Thanksgiving at CRU beat going home for the holidays?

A face from Lightman’s past pulls him into a dangerous criminal conspiracy, testing his friendship and loyalty. Meanwhile, The Lightman Group investigates a high school student’s homicidal threats.

Dan brings Renee onto his television show, leaving Nathan and Haley powerless to stop him from revealing the truth of her pregnancy to the world. Quinn examines what went wrong with David, and Sara and Clay discuss their past. Meanwhile, Brooke comes clean with Julian about her true desires.

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The Walker family, with the exception of Nora, are surprised by the charms and tango lessongs of Luc Laurent, Sarah’s new lover. However, Nora quickly uncovers that her French houseguest is a very good comfort during a very difficult time. Meanwhile, Robert needs to distract Kitty from the cancer, and he uses his most romantic efforts into the situation.

When Juanita’s party is on the verge of being ruined after Gaby is deemed a bad mom, Gaby is determined to prove she’s a responsible parent; Bree gets defensive when she’s judged by a motel maid for having an affair with Karl; Lynette is put off by her new handyman when he defers to Tom for approval on all things; and Susan and Katherine come to blows over Mike. Meanwhile, a lapse in judgment on Danny’s part leads to a terrible mishap that Angie and Nick must cover up.

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Dexter is inspired to investigate the Trinity Killer on his own, while Debra blames herself for an event that was out of her control, and Rita realizes how little she knows her husband after discovering one of his secrets.

A woman forces Oliver to play in a dangerous game and then turns up dead. The police believe Oliver is responsible and arrest him. Meanwhile, Lois confronts Clark over his knowledge about Oliver’s suicide attempt.

When a burn victim unexpectedly dies in the E.R., all the Mercy West and Seattle Grace residents must defend their actions in hopes of saving their jobs.

Jack tries to protect his job and the company when Devin returns to seek revenge; Tracy and Jenna try to make Liz’s life miserable; Kenneth volunteers at an animal shelter.

Michael shocks Pam and Jim when he reveals the identity of his new girlfriend; Dwight offers Jim a strange peace offering.